Principal Scientist - Analytical Chemistry



Thousand Oaks, CA, USA
Posted on Thursday, May 4, 2023


If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of.

Principal Scientist – Analytical Chemistry


What you will do

Let’s do this. Let’s change the world. In this vital role you will The manage the Synthetic Separations group, supervising and mentoring staff, prioritizing workload, designing the future state of the group, and serving as a technical expert for the group.

Key Responsibilities:

  • The successful candidate will manage the Synthetic Separations group, supervising and mentoring staff, prioritizing workload, designing the future state of the group, and serving as a technical expert for the group.
  • You will develop custom separation, detection, and quantitation methods to solve analytical problems encountered in various areas of small, hybrid, and large molecule discovery.
  • Utilization of a diverse set of instruments and technologies, such as (but not limited to) HPLC, SFC-MS, HPLC-MS, CE, mass-directed purification, and preparative SFC is necessary.
  • In addition, you will support drug discovery teams by developing chromatographic methods and processes for the analysis and purification of small and hybrid (mRNA, LNP, siRNA, peptides, and oligonucleotides) molecules to support discovery efforts.
  • The successful candidate is also expected to actively participate in research efforts directed at improving process efficiencies, expanding the range of assays and applications, and improving technologies and infrastructure, from conceptualizing to experimental design through implementation.
  • Additional responsibilities include participating in national and international scientific meetings and providing scientific reports that support the generation of publications, patents, or regulatory submissions.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a Principal Scientist with these qualifications.

Basic Qualifications:

Doctorate degree and 3 years of scientific experience OR

Master’s degree and 6 years of scientific experience OR

Bachelor’s degree and 8 years of scientific experience

Preferred Qualifications:

Doctorate degree and 6+ years of post-doctorate experience in academia or the biopharmaceutical industry.

Possess an in-depth understanding of analytical and purification processes to support small, hybrid (mRNA, LNP, peptides, siRNA, oligonucleotides), and large molecules.

Two years of experience with mRNA/LNP analysis and/or purification.

Established scientific reputation in the field of chromatographic sciences as evidenced by external publications and presentations.

Strong working knowledge of drug discovery and the development of therapeutics.

Experience working in a cross-functional, matrixed, and global research organization.

Demonstrated ability to recruit, lead and motivate a team of scientists, and to be actively engaged in their career development.

Outstanding leadership, interpersonal and communication skills.


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is $164,839-184,739.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancers, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.